Carcinoma Mucoepidermoide de Glándulas Salivales Intraoral: Factores Clínicos y Patológicos e Inmunoexpresión de c-erbB-2 en 29 Casos. Vanessa Fátima. Abstract. AVILA, Rodolfo Esteban et al. Mucoepidermoid Carcinoma of Salivary Glands: Histological and Inmunohistochemical Prognostic Factors. Publisher: El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el.

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MEC is reported to manifest variable biologic aggressiveness, basically showing correlation with its histological features and is graded by a 3-tiered system Auclair et al, The Kaplan-Meier method was used to plot survival curves with the log rank test for analysis of cumulative survival rates.

Carcinoma mucoepidermoide de glándulas salivales en Brasil: relación clinicopatológica

Coexpression of p53 and c-erbB-2 proteins is associated with histological type, tumour stage, and cell proliferation in malignant salivary gland tumours.

Tumors were more common in the third and fourth decades salivaled life Even though low-grade tumors did not develop metastases and high-grade tumors showed lower DFS rates after five years, no significant difference was found for the grading system or any of the evaluated prognostic factors. Clinicopathologic and muocepidermoide study of intraoral mucoepidermoid carcinoma.

Mucoepidermoid carcinoma of the salivary glands.

Due to the singularity and diverse histology of these tumors, prognostic factors have been difficult to elucidate. Histologically, the tumors were classified as low, intermediate and high grade, according to Auclair et al. In the present study, was set out to examine MEC behavior and patient outcomes to provide additional information on potential factors that could significantly affect the prognosis of these tumors. Through a long follow-up period in present study we could highlight the relevance of primary anatomical site, tumor size and metastasis as useful prognostic factors that may affect survival in patients with a primary diagnosis of head and neck mucoepidermoid carcinomas.


Inmunostaining for ki67 were made. MECs were staged according to the TNM classification of malignant tumors, 12 and minor salivary gland tumors were staged according to their site of origin in a similar fashion to squamous cell carcinomas. Low grade tumors seem to arise more often in minor salivary glands, which according to some authors are detected at earlier stages, probably due to the less aggressive growth in addition to a better visible tumor site.

Concerning MEC, there had been only individual case descriptions of c-erbB-2 expression Kernohan et al.

Casilla D Temuco – Chile Tel.: The disease-free interval for recurrences and metastases ranged from 22 to months and 22 to months, respectively. All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License.

Carcinoma mucoepidermoide

Clinicopathologic and immunohistochemical study of intraoral mucoepidermoid carcinoma. Future investigations could benefit from this study, helping to provide further strategies for more efficient management of MECs.

MEC is composed of varying proportions of mucous, epidermoid, columnar, intermediate and clear cells Auclair et al. Intraoral mucoepidermoid carcinoma of salivary glands. Mucoepidermoid carcinoma of the major salivary glands: This antibody although less sensitive than the polyclonal antibody glahdulas in other reports Lopes et al. Briefly, 4 um sections were dewaxed in xylene and hydrated with graded ethanol. Evaluation and application of grading criteria in cases.


Although the latter may present myoepitelial derivation, carcinoma ex pleomorphic adenoma probably adquired a particular biological behavior in the longstanding process of malignant transformation. Sinonasal and maxillary tumors were not included in the sample.

The c-erbB-2 oncoprotein is involved in matrix degradation and proteolitic activity as well as in the increase in vessel permeability, endothelial cell growth, proliferation, migration, mucopidermoide differentiation Verbeek et al.

Tumors were stratified into three groups: Carcinoma ex pleomorphic adenoma of the salivary gland: Mucoepidermoid carcinoma of minor salivary glands: High grade tumors, on the other hand, seem to arise more often in major salivary glands Kokemueller et al.

However, in the study of Lopes et al. Expression of c-erbB-2 oncoprotein in salivary gland tumours: Selecting antibodies to detect HER2 overexpression by immunohistochemistry in invasive mammary carcinomas. The palate was the most commonly affected site, with 21 cases Disease-free survival rates were In contrast to results reported by Nance and others 4 in present study was not observed any association between positive surgical margins and decreased DFS.

Pattern of parotid gland tumors on Crete, Greece: Otolaryngol Head Neck Surg.